Download Antimicrobial drug discovery : emerging strategies by George Tegos, Eleftherios Mylonakis PDF

By George Tegos, Eleftherios Mylonakis

Drug resistance is expanding between a number of human pathogenic microorganisms equivalent to Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as probably the most vital scientific demanding situations of this century. elevated basic expertise and worry of those pathogens potential there's a transforming into call for for study to take on the specter of multidrug resistance. Documenting the newest study within the box, this ebook discusses present and promising actions to find new antimicrobials in 5 key parts: molecular genetics and platforms microbiology; artificial, computational chemistry and chemoinformatics; excessive Throughput Screening (HTS); non-vertebrate version hosts; and light-weight- and nano-based applied sciences.

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Street, C. and Wilson, M. (2009) In vivo killing of Staphylococcus aureus using a light-activated antimicrobial agent. BMC Microbiology 9, 27. 2 The Antibiotic Crisis Arnold L. Demain1 and Jaroslav Spizek2 Charles A. 1 The Problem The golden era of antibiotic discovery occurred from 1950 until 1970. ’ Microbiologists knew at that time that technology had not yet won the war against infectious microorganisms due to resistance development in pathogenic microbes and other problems. Resistance of bacteria to antibiotics continues to increase.

And Schuch, R. (2006) Reinventing phage therapy: are the parts greater than the sum? Nature Biotechnology 24, 1508–1511. Fisher, K. and Phillips, C. (2009) The ecology, epidemiology and virulence of Enterococcus. Microbiology 155, 1749–1757. C. S. (2009) The antibacterial effect of photodynamic therapy in dental plaque-derived biofilms. Journal of Periodontal Research 44, 751–759. , Farr-Jones, S. A. (1999) High throughput screening for drug discovery: continually transitioning into new technology.

One is the existence of naturally resistant bacteria, such as P. aeruginosa, Stenotrophomonas maltophilia, E. faecium, Burkholderia cepacia and A. baumannii (Tenover and Hughes, 1996). , 1996), and the organisms causing TB and malaria. Resistance is due to inactivation by enzymes such as b-lactamase, increased efflux of the antibiotic out of cells, decreased uptake of the antibiotic, modification of the target to decrease binding of the antibiotic, amplification of the target, bypassing the essentiality of the target, sequestration of the antibiotic, protection of the target, intracellular localization and biofilm formation (Singh and Barrett, 2006; Davies, 2007).

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